Jason Matthews
Medlem i faggruppen for kontaminanter i mat, ph.d.
Kontaminanter i mat
Professor. Molekylær ernæring. Jason Matthews har doktorgrad i biokjemi og toksikologi. Hans nøkkelkompetanse innenfor VKMs fagområder er molekylær toksikologi og miljøgifter i mat.
Mobiltelefon: 97122798
E-post: jason.matthews@medisin.uio.no
Stilling
Førsteamanuensis, Norges miljø- og biovitenskapelige universitet (NMBU), Veterinærhøgskolen, Institutt for parakliniske fag, faggruppe farmakologi.
Utdanning
2001 Ph.D., Biochemistry Environmental Toxicology, Michigan State University, East Lansing MI USA
1997 H.BSc. Toxicology and Environmental Sciences, Western University, Ontario, Canada
Arbeidserfaring
2015-nå Professor Department of Nutrition, University of Oslo
2016-nå Status only Associate Professor, Dept of Pharmacology and Toxicology University of Toronto
2011-2015 Associate Professor, Dept of Pharmacology and Toxicology University of Toronto, Canada
2006-2011 Assistant Professor, Dept of Pharmacology and Toxicology, University of Toronto, Canada
2001-2006 Postdoctoral Fellow, Dept of Biosciences and Nutrition Karolinska Institute, Sweden
Øvrig faglig bakgrunn
2020 - 2024 Europeisk Registrert Toksikolog (ERT)
2019 - 2023 Leder av Toksikologi seksjon av Norske selskap for farmakologi og toksikologi
2011 - 2013 Styremedlem, Society of Toxicology Canada
Utvalgte publikasjoner
Bobrovs, R., Olafsen, N.E., Åhrling, S.S., Matthews, J. Aryl Hydrocarbon Receptor Pharmacology - Mechanisms, Ligands, and Therapeutic Potential. 2026. Pharmacological Reviews. 2026. 78 100146.
Kannen V, Olafsen NE, Das S, Giuliana P, Izzati FN, Choksi H, Åhrling SS, Cappello P, Teino I, Maimets T, Jaudzems K, Gulbinas A, Dambrauskas Z, Edgar LJ, Grant DM, Matthews J. Loss of aryl hydrocarbon receptor reduces pancreatic tumor growth by increasing immune cell infiltration. Biochem Pharmacol. 2025 Jun;236:116872. doi: 10.1016/j.bcp.2025.116872. Epub 2025 Mar 14. PubMed PMID: 40090596.
Das S, Somisetty VS, Ulven SM, Matthews J. Resveratrol and 3,3'-Diindolylmethane Differentially Regulate Aryl Hydrocarbon Receptor and Estrogen Receptor Alpha Activity through Multiple Transcriptomic Targets in MCF-7 Human Breast Cancer Cells. Int J Mol Sci. 2023 Sep 26;24(19). doi: 10.3390/ijms241914578. PubMed PMID: 37834026; PubMed Central PMCID: PMC10572670.
Alvik K, Shao P, Hutin D, Baglole C, Grant DM, Matthews J. Increased sensitivity to chemically induced colitis in mice harboring a DNA-binding deficient aryl hydrocarbon receptor. Toxicol Sci. 2023 Feb 17;191(2):321-331. doi: 10.1093/toxsci/kfac132. PubMed PMID: 36519841; PubMed Central PMCID: PMC9936212.
Hutin D, Long AS, Sugamori K, Shao P, Singh SK, Rasmussen M, Olafsen NE, Pettersen S, Grimaldi G, Grant DM, Matthews J. 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (TiparpH532A) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality. Toxicol Sci. 2021 Aug 30;183(1):154-169. doi: 10.1093/toxsci/kfab075. PubMed PMID: 34129049; PubMed Central PMCID: PMC8404992.