The Norwegian Scientific Committee for Food Safety (VKM) has on request from the Norwegian Food Safety Authority conducted a risk categorisation of about 30 amino acids and amino acid compounds based on potential health risks related to high intakes of the amino acids.
The task has been conducted by the VKM Panel on Nutrition, Dietetic Products, Novel Food and Allergy.
The Norwegian Food Safety Authority asked VKM to categorise the amino acids into low, moderate or high risk groups. The three categories are identified by the following criteria:
A broad literature search was conducted in the MEDLINE database. VKM found few relevant studies focusing on potential negative health effects for most of the amino acids. Amino acids have a high bioactive potential, and thus VKM concluded that amino acids that are not included in human studies or that are poorly studied may represent a moderate risk.
No tolerable upper intake levels are established for the individual amino acids. The Panel has suggested the following categories:
The Norwegian Food Safety Authority has announced that they will request risk assessments of the amino acids that may represent a high risk according to this grouping. The scientific literature on potential negative health effects from high intakes of amino acids in supplements is in generally scarce.